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RFantibody — Vecura
RFantibody
Structure-based de novo antibody and nanobody design pipeline combining an antibody-finetuned RFdiffusion for backbone design, ProteinMPNN for CDR sequence design, and an antibody-finetuned RoseTTAFold2 for in silico filtering.
Upload a target PDB above to choose a chain.
Single-domain heavy chain (H). Has the three heavy loops H1-H3; L1-L3 do not exist for it.
Choose a framework or upload one.
Upload a target PDB to pick hotspots visually, or type them here (e.g. A56,B20).
Heavy
Light
H1–
H2–
H3–
Leave a loop's length blank to keep the framework's own length; enter one number to fix it, or min–max for a range.
Reproduce identical backbones across runs when enabled.