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mBER Open — Vecura

mBER Open

De novo VHH nanobody binder design via AlphaFold-Multimer backpropagation optimization with ESM2 sequence conditioning.

Job Name

Target Protein (PDB)*

Target Chain(s)*

Hotspot Residues

Upload a target PDB to pick hotspots visually, or type them here (e.g. A56,B20).

Number of Accepted Binders

VHH Framework (Masked CDRs)

CDR1

9

CDR2

11

CDR3

12

EVQLVESGGGLVQPGGSLRLSCAASG*********WFRQAPGKEREF***********NADSVKGRFTISRDNAKNTLYLQMNSLRAEDTAVYYC************WGQGTLVTVSS

32 designable · 86 framework · 118 total aa

Max Trajectories

Minimum iPTM

Minimum pLDDT

Configure input settings on the left, then click "Run"