ESM-Scan predicts the functional impact of every possible amino-acid substitution in a protein sequence (in silico saturation mutagenesis) using Meta AI's ESM-1v / ESM-1b protein language models. It is a thin wrapper around the fair-esm `predict.py` example that adds (a) automatic generation of all 20*L single-AA mutants for a given sequence, (b) optional scoring of a user-supplied set of substitutions or indels, and (c) heatmap, boxplot, and ClinVar pathogenic/benign density-plot visualisations.