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BindCraft — Vecura

BindCraft

Automated protein binder design pipeline combining AlphaFold2 backpropagation, ProteinMPNN sequence optimization, and PyRosetta relaxation/scoring to generate novel binder sequences and structures targeting specified protein surfaces.

Job Name

Target Protein (PDB)*

Target Chain(s)*

Upload a target PDB above to choose a chain.

Hotspot Residues

Binder Length Min

aa

Binder Length Max

aa

Number of Final Designs

Design Algorithm

Design Recycles

Validation Recycles

Omit Amino Acids

Force Reject Omitted AAs

Enable MPNN Redesign

MPNN Sequences Per Trajectory

MPNN Sampling Temperature

Random Seed

Configure input settings on the left, then click "Run"